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International Affairs Students Current Students Alumni Faculty/Staff Careers--> TOHOKU UNIVERSITYCREATING GLOBAL EXCELLENCE Search 日本語 Contact Tohoku University --> About Facts & Figures Facilities Organization Chart History President's Message Top Global University Project Designated National University Global Network Promotional Videos Academics Undergraduate Graduate Courses in English Exchange Programs Summer Programs Double Degree Programs Academic Calendar Syllabus Admissions Undergraduate Admissions Graduate Admissions Fees and Expenses Financial Aid Research Feature Highlights Research Releases University Research News Research Institutes Visitor Research Center Research Profiles Academic Research Staff Campus Life International Support Office IT Services Facilities Dining & Shops Campus Bus Clubs & Circles News University News Research--> Arts & Culture Health & Sports Campus & Community Press Release--> International Visit Alumni Careers Events Exhibits Music Special Event Lecture Alumni--> Map & Directions Campus Maps & Bus--> Facilities Map--> TOHOKUUNIVERSITY About Academics Admissions Research Campus Life News Events International Affairs Students Current Students Alumni Faculty/Staff Promotional Videos Subscribe to our Newsletter Map & Directions Contact Jobs & Vacancies Emergency Information Site Map 日本語 Close Home Research News New Rapid Prototyping Method for Microscale Spiral Devices Research News New Rapid Prototyping Method for Microscale Spiral Devices 2024-01-26 A team of researchers from Tohoku University and Okinawa Institute of Science and Technology (OIST) has achieved significant advancement in the field of microfluidics, allowing for precise and efficient manipulation of fluids in three-dimensional microscale environments. This work opens up new possibilities for bioanalytical applications, such as cell separations in the realm of medical diagnostics. Details of their breakthrough were published in the journal Microsystems and Nanoengineering on January 22, 2024. Microfluidic devices are designed to handle minuscule fluid volumes, allowing researchers to perform analyses and processes with remarkable precision and efficiency. In recent years, microfluidic technology has rapidly advanced across various fields, including medicine, biology, and chemistry. Among them, three-dimensional spiral microfluidic devices stand out as game-changers. Their intricate corkscrew-like design allows for precise fluid control, efficient particle separation, and reagent mixing. However, their potential to revolutionize bioanalytical applications is hindered by the current challenges in fabrication. The process is time-consuming and costly, and existing manufacturing techniques limit material options and structural configurations. To overcome these limitations, an interdisciplinary team from Tohoku University and OIST has introduced a miniaturized rotational thermal drawing process (mini-rTDP), drawing inspiration from traditional Japanese candy-making techniques - the fabrication of Kintaro-ame. Conceptional diagram: Twisted Fiber Microfluidics. ©Kato et al. Their innovative approach involves rotating the materials during thermal stretching to create intricate three-dimensional structures within fibers. This process is highly versatile, accommodating a wide range of materials that can deform when heated, unlocking endless possibilities for combining diverse materials. "Mini-rTDP facilitates rapid-prototyping of three-dimensional microfluidic systems, ideal for precise biofluid manipulation," points out Yuanyuan Guo, an associate professor at Tohoku University's Frontier Research Institute for Interdisciplinary Sciences (FRIS). "Mini-rTDP involves creating a molded polymer preform containing channels, which are subsequently stretched and heated to generate microfluidic channels within a fiber. These channels can then be further rotated to shape three-dimensional spiral configurations," explained Shunsuke Kato, a junior researcher at FRIS and the first author of the paper. The fabrication procedure of creating 3D spiral fibers.©Kato et al. In collaboration with Amy Shen, leader of the Micro/Bio/Nanofluidics Unit at OIST, the interdisciplinary Tohoku-OIST team conducted both simulations and experiments to visualize fluid flows within the spiral structures. Daniel Carlson from Shen's group remarked, "We have confirmed the presence of Dean vortices, a type of rotational flow occurring in curved channels, in our devices, thus affirming their potential for significantly enhancing cell and particle separation efficiency." "The rapid prototyping of three-dimensional spiral microfluidics using mini-rTDP represents a remarkable advancement in the field of microfluidics. This technology offers unparalleled versatility, precision, and the potential to catalyze transformative changes across various industries," highlights Shen. "Furthermore, we are actively pursuing the integration of microfluidic channels with functionalities such as electrodes, biosensors, and actuators directly into fibers. This endeavor has the potential to revolutionize Lab-on-Chip bioanalytical technologies," elaborates Guo. The prototyped fiber with internal spirals.©Kato et al. This research is a testament to the collaborative efforts of the OIST SHIKA program and the matching funds provided by Tohoku University, highlighting the strong partnership and synergy between these two institutions. Publication Details: Title: Twisted Fiber Microfluidics: A Cutting-Edge Approach to 3D Spiral DevicesAuthors: Shunsuke Kato, Daniel W. Carlson, Amy Q.Shen, Yuanyuan GuoJournal: Microsystems and NanoengineeringDOI: 10.1038/s41378-023-00642-9 Press release in Japanese Contact: Yuanyuan Guo,FRISEmail: yyuanguofris.tohoku.ac.jpWebsite: https://sites.google.com/view/neuroelectronics/?pli=1 --> Archives 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 Page Top About Tohoku University Academics Admissions Research Campus Life News Events International Affairs Students Alumni Promotional Videos Subscribe to our Newsletter Map & Directions Contact Tohoku University Jobs & Vacancies Emergency Information Site Map Privacy Policy Media Enquiries Parent & Family Support Public Facilities Contact Tohoku University

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