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順天堂大学 大学院医学研究科 環境医学研究所Center of Sportology 当研究所について 概要 大学院教育 研究施設・設備 文部科学省支援事業 産学協同研究 メンバー 所長 副所長 スタッフ 運営委員（学内） 研究スタッフ 客員教授 教育・研究 概要 教育指導目標 かゆみの研究 眼アレルギーの研究 糖脂質を介した分化・免疫機構の研究 プロテオミクス研究 自己免疫疾患の研究 業績 かゆみの研究 眼アレルギーの研究 糖脂質を介した分化・免疫機構の研究 プロテオミクス研究 自己免疫疾患の研究 かゆみ研究センター かゆみと真剣勝負 English アクセス English かゆみ研究センター かゆみと真剣勝負 プロテオミクス研究 業績プロテオミクス研究 業績一覧 2020年 Yanagida Y, Namba M, Fukuta T, Yamamoto H, Yanagida M, Honda M, Oku N, Asai T: Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury. Biochem Biophys Res Commun, 2020; 531: 622-627. Tanaka K, Tanaka T, Nakano T, Hozumi Y, Yanagida M, Araki Y, Iwazaki K, Takagi M, Goto K: Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. Cell Signal, 2020; 65: 109428. Araki Y, Yanagida M: Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome. Adv Clin Chem, 2020; 94: 1-30. 2019年 Yanagida M, Hamamura K, Takamori K, Araki Y: The simultaneous quantification of candidate serum biomarker peptides for hypertensive disorders of pregnancy. Ann Clin Biochem, 2019; 56: 457-465. 2018年 Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y: Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multidimensional peptide analysis in females with pregnancy-induced hypertension. Ann Clin Biochem, 2018; 55: 287-295. 2016年 Yoshitake H, Oda R, Yanagida M, Kawasaki Y, Sakuraba M, Takamori K, Hasegawa A, Fujiwara H, Araki Y: Identification of an anti-sperm auto-monoclonal antibody (Ts4)-recognized molecule in the mouse sperm acrosomal region and its inhibitory effect on fertilization in vitro. J Reprod Immunol, 2016; 115: 6-13. Misaki K, Takamura-Enya T, Ogawa H, Takamori K, Yanagida M: Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives. Mutagenesis, 2016; 31: 205-213. Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y: Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. Ann Clin Biochem, 2016; 53: 85-96. 2015年 Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K: Properties and functions of lactosylceramide from mouse neutrophils. Glycobiology, 2015; 25: 655-668. Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y: Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis. Autoimmunity, 2015; 48: 251-258. 2013年 Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I: Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab, an anti-interleukin-6 receptor antibody. Biomed Res Int, 2013; 2013: 607137. Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I: Inhibition of connective tissue growth factor ameliorates rheumatoid arthritis in a murine model. Arthritis Rheum, 2013; 65: 1477-1486. 2012年 Fu L, Kitamura T, Iwabuchi K, Ichinose S, Yanagida M, Ogawa H, Watanabe S, Maruyama T, Suyama M, Takamori K: Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. World J Gastroenterol, 2012; 18: 5034-5041. Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I: Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheumatic Dis, 2012; 15: 486-495. Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Topham MK, Martelli AM, Goto K: DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cell Signal, 2012; 24: 1573-1582. Okada M, Hozumi Y, Iwazaki K, Misaki K, Yanagida M, Araki Y, Watanabe T, Yagisawa H, Topham MK, Kaibuchi K, Goto K: DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem Biophys Res Commun, 2012; 420: 479-484. Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I: Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol, 2012; 22: 228-237. 2011年 Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee L, Tanaka K: Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: Its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension. Proteomics, 2011; 11: 2727-2737. Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y: Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. J Reprod Immunol, 2011; 90: 202-213. 2009年 Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I: Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther, 2009; 11: R174. Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K: Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse. Biol Reprod, 2009; 81: 889-897. Fujiyama-Nakamura S, Yoshikawa H, Homma K, Hayano T, Tsujimura-Takahashi T, Izumikawa K, Ishikawa H, Miyazawa N, Yanagida M, Miura Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N: Parvulin (Par14), a peptidyl prolyl cis-trans isomerase, is a novel rRNA-processing factor evolved in the metazoan lineage. Mol Cell Proteomics, 2009; 8: 1552-1565. 2008年 Izumikawa K, Yanagida M, Hayano T, Tachikawa H, Komatsu W, Shimamoto A, Futami K, Furuichi Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N: Association of human DNA helicase RecQ5β with RNA polymerase II and its possible role in transcription. Biochem J, 2008; 413: 505-516. Sekigawa I*, Yanagida M*, Iwabuchi K, Kaneda K, Kaneko H, Takasaki Y, Jung G, Sone S, Tanaka Y, Ogawa H, Takamori K: Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor- antibody therapy. Clin Exp Rheumatol, 2008; 26: 261-267. *: equal contribution Hayashi C*, Ono Y*, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H: Multiple molecular interactions implicate Connectin/Titin N2A region as a modulating scaffold for p94/Calpain 3 activity in skeletal muscle. J Biol Chem, 2008; 283: 14801-14814. *: equal contribution Morigasaki S, Shimada K, Ikner A, Yanagida M, Shiozaki K: Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Mol Cell, 2008; 30: 108-113. Yanagida M, Iwabuchi K: Proteomic analysis of lactosylceramide-enriched membrane microdomains. Trends Glycosci Glycotech, 2008; 20: 1-15. 2007年 Ono Y, Hayashi C, Doi N, Kitamura F, Shindo M, Kudo K, Tsubata T, Yanagida M, Sorimachi H: Comprehensive survey of p94/calpain 3 substrates by comparative proteomics &＃8211; Possible regulation of protein synthesis by p94. Biotechnol J, 2007; 2: 565-576. Yanagida M, Nakayama H, Yoshizaki F, Fujimura T, Takamori K, Ogawa K, Iwabuchi K: Proteomic analysis of plasma-membrane lipid rafts of HL-60 cells. Proteomics, 2007; 7: 2398-2409. 2006年 Tsukamoto H, Yoshitake H, Mori M, Yanagida M, Takamori K, Ogawa H, Takizawa T, Araki Y: Testicular proteins associated with the germ cell-marker, TEX101: Involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis. Biochem Biophys Res Commun, 2006; 345: 229-238. Sekiguchi T, Hayano T, Yanagida M, Takahashi N, Nishimoto T: NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Nucleic Acids Res, 2006; 34: 4593-4608. 業績 かゆみの研究眼アレルギーの研究糖脂質を介した分化・免疫機構の研究プロテオミクス研究自己免疫疾患の研究 環境医学研究所Institute for Environmental and Genter-Specific Medicine 順天堂大学・大学院 順天堂 医学部附属 浦安病院 アクセス プライバシーポリシー 〒279-0021　千葉県浦安市富岡2-1-1　2号館8階 Copyright © JUNTENDO All rights reserved.