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Prof. Takuya Mabuchi Tohoku Univ.Database--> Title Development of high-sensitive method to detect aberrant proteins Priod 2020-2021 Accumulation of peptide/protein aggregates is a common morphological feature, leading cause of many neurodegenerative diseases such as Parkinson&＃39;s disease, Alzheimer&＃39;s disease, and amyotrophic lateral sclerosis (ALS). A sensitive method for detecting protein aggregates in mixtures of blood and cell-derived components has not yet been established for these diseases. A development of an in situ peptide/protein aggregate detection method is robustly desired. The present research therefore focuses on the establishment of a new method for the sensitive detection of peptide/protein aggregation in cell-derived components by utilizing the amino acid residue-specific modification (e.g. cysteine and tyrosine) to understand the proteins aggregation mechanism in vivo. This project is an interdisciplinary research that can be accomplished only by fusing different scientific disciplines and enhancing mutual understanding and cooperation among researchers from different fields; Dr. Mabuchi (Computational Science; Selection of compounds and molecules), Dr. Sato (Organic Chemistry; Synthesis of compounds), and Dr. Okumura (Protein Science; Biological evaluation). The significance of this interdisciplinary research proposal is to create novel molecules and develop strategies for the very early diagnosis of related diseases. We aim to apply the results of "detecting the aggregation process and the aggregation state of proteins/peptides" not only to basic researches in medicine, agriculture, biology, computational science, chemistry, and pharmacology, but also to detection methods and drug discoveries for definitive treatment of diseases related to proteins/peptides aggregations.   PAGE TOP Frontier Research Institute for Interdisciplinary Sciences About FRIS GreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingConsultation Desk Researcher Advanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Feature TopicsFRIS InterviewsFRIS Hub Meeting Research Programs Open Research ProposalResearch Projects Recruit Open Staff PositionsHandbook for International Researchers FRIS CoRE FRIS CoRE FRIS Fund FRIS Fund for Early-Career Independent Researchers External Links for Early Career Researcher Support Division for Interdisciplinary Advanced Research and Education (DIARE) Ensemble Project for Early Career Researchers Support Program for the Article Processing Charge webmail LINK Copyrights © Frontier Research Institute for Interdisciplinary Sciences, Tohoku University All rights reserved. no cache