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About KMS About Message from the Dean Campus Outline Outline Organization chart History Kochi Medical School Outline Facilities Facility list kochi Medical School Hospital Center of Medical Information Science Center for Innovative and Translational Medicine Center for Photodynamic Medicine Center for Medical Education Development Library and Imformation Technology, Medical School Branch Campus life Campus life International Exchanges International Exchanges To Prospective International Students Overseas partner schools Health Service Center,Medical School Branch(Oko Campus) Access Education Education Medical department Medical department Medical Course Medical Course Neurobiology and Anatomy Pathology Physiology Cardiovascular Control Biochemistry Functional Genomics Molecular Biophysics Pharmacology Microbiology and Infection Parasitology Immunology Legal Medicine Environmental Medicine Public Health Hospital Administration Section Liaison Healthcare Engineering Section Laboratory Medicine Diagnostic and Interventional Radiology Radiation Oncology Anesthesiology and Intensive Care Medicine Gastroenterology and Hepatology Endocrinology, Metabolism & Nephrology Respiratory Medicine and Allergology Hematology Cardiology and Geriatrics Medical Oncology Neurology Clinical Infectious Diseases Dermatology Pediatrics Obstetrics and Gynecology Neuropsychiatry Gastroenterological Surgery Breast Surgical Oncology Pediatric Surgery Cardiovascular Surgery General Thoracic Surgery Clinical Oncology and Minimally Invasive Surgery Plastic and Reconstructive Surgery Orthopaedic Surgery Urology Ophthalmology Otolaryngology, Head and Neck Surgery Neurosurgery Oral and Maxillofacial Surgery Disaster and Emergency Medicine Family Medicine Child and Adolescent Psychiatry Medical Virtual Reality Crisis Management Medicine Clinical Epidemiology Kochi-Umajimura Yuzu Health Research Course YAMAKIN Next Generation Dental Medical Development Lecture Molecular and Cellular Biology Nursing Course Graduate School Graduate School Medical Science(Master's Course) Medical Science(Master's Course) Medical Science Course Public Health Course Healthcare Innovation Course Nursing Science(Master's Course) Medicine(Doctoral Course) Medicine(Doctoral Course) Life Science Course Clinical Science Course Information Healthcare Science Course Neurology/Psychiatry in Child and Adolescence Course MD-PhD Course Ocean and Medicine Course About KMS A Message from the Dean Campus map Outline Organization chart History Kochi Medical School Outline Facilities Kochi Medical School Hospital Center of Medical Information Science Center for Innovative and Translational Medicine Center for Photodynamic Medicine Center for Medical Education Development Library and Imformation Technology, Medical School Branch Campus life International Exchanges To Prospective International Students Overseas partner schools Health Service Center,Medical School Branch(Oko Campus) Access Education Medical department Medical Course Neurobiology and Anatomy Pathology Physiology Cardiovascular Control Biochemistry Functional Genomics Molecular Biophysics Pharmacology Microbiology and Infection Parasitology Immunology Legal Medicine Environmental Medicine Public Health Hospital Administration Section Liaison Healthcare Engineering Section Laboratory Medicine Diagnostic and Interventional Radiology Radiation Oncology Anesthesiology and Intensive Care Medicine Gastroenterology and Hepatology Endocrinology, Metabolism & Nephrology Respiratory Medicine and Allergology Hematology Cardiology and Geriatrics Medical Oncology Neurology Clinical Infectious Diseases Dermatology Pediatrics Obstetrics and Gynecology Neuropsychiatry Gastroenterological Surgery Breast Surgical Oncology Pediatric Surgery Cardiovascular Surgery General Thoracic Surgery Clinical Oncology and Minimally Invasive Surgery Plastic and Reconstructive Surgery Orthopaedic Surgery Urology Ophthalmology Otolaryngology, Head and Neck Surgery Neurosurgery Oral and Maxillofacial Surgery Disaster and Emergency Medicine Family Medicine Child and Adolescent Psychiatry Medical Virtual Reality Crisis Management Medicine Clinical Epidemiology Kochi-Umajimura Yuzu Health Research Course YAMAKIN Next Generation Dental Medical Development Lecture Molecular and Cellular Biology Nursing Course Graduate School Medical Science Program (Master’s Course) Medical Science Course Public Health Course Healthcare Innovation Course Nursing Science(Master's Course) Medicine(Doctoral Course) Life Science Course Clinical Science Course Information Healthcare Science Course Neurology/Psychiatry in Child and Adolescence Course MD-PhD Course Ocean and Medicine Course Search Access Language Japanese English EDUCATION Department of Endocrinology, Metabolism & Nephrology HOME Education About medical school Medical Course Department of Endocrinology, Metabolism & Nephrology Overview Nephrology and Rheumatology Kidney is the indispensable organ that plays an important role in multiple functions maintaining metabolism, electrolyte balance, body fluid adjustment, etc. Kidney diseases include not only primary diseases, e.g. IgA nephropathy, minimal change disease, but also secondary to other systemic diseases, e.g. infection, collagen diseases, metabolic diseases, and drug-induced. Worldwide, patients with end-stage renal diseases (ESRD) and subsequent renal replacement therapy (RRT) is increasing steadily. To date, the number of patients with RRT in Japan surpassed 300,000 and this causes an increase of national medical expenses, so prevention of renal dysfunction progress should be accomplished immediately. In the purpose as mentioned above, KDIGO had proposed the disease concepts chronic kidney disease (CKD) and acute kidney injury (AKI) for early diagnosis and clarifying their epidemiology. In our department, many specialists in the areas of nephrology, rheumatology and metabolism perform management of various diseases, and research kidney diseases by both experimental and clinical approach. Diabetes Diabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complication and to reduce the risk of long-term complications. Management and education of diabetes for each patient is performed both by diabetologist and by co-medical stuff including nutritionist, nurse, physical therapist, pharmacist, and medical technologist. In our department, clinical problems of patients with diabetes are solved by many Board Certified Diabetologists, Certified Diabetes Educator of Japan, and other co-medical stuffs belonging to Diabetes Care Support Team. Endocrinology Endocrinology is an essential field of clinical internal medicine, because hormonal system is required to maintain homeostasis in human physiology. Endocrinology has the old history, and 98th American Endocrine Society meeting and 89th Japan Endocrine Society meeting will be held in 2016. Our department is working as a center of clinical endocrinology in Kochi prefecture, and endocrine patients (e.g. pituitary, thyroid, adrenal diseases) and also obesity patients are properly diagnosed and treated. Because several cases are difficult to treat, we have clinical conference weekly. In the cases of patients need for surgery, we have careful discussion with endocrine surgeon or neurosurgeon. It’s important to study the way of diagnosis and treatment in each case for educating resident, and it’s encouraged to make case reports for understanding endocrine disease. Research areas Nephrology and Rheumatology 【Molecular mechanism of autophagy in AKI】Autophagy is one of important factors which play a pivotal role in AKI. We proposed that Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in AKI and that oxidative stress-induced apoptosis is ameliorated by HSPB1, reportedly regulate autophagy. Furthermore, we reported that 5-Aminolevulinic acid (ALA) has protective effect in cisplatin-induced AKI is via protection of mitochondrial viability and prevents tubular apoptosis. 【Analysis of clinical data to elucidate pathophysiology of AKI and CKD】We investigate the biomarkers and epidemiology of CKD and AKI. We had already reported that soluble secreted α-Klotho could be a probable novel biomarker for CKD and that serum uric acid level is a risk factor for AKI in hospitalized patients. Diabetes 【Molecular mechanism of impaired insulin secretion in diabetes】One of the characteristics of type 2 diabetes is that the insulin secretory response of β-cells is selectively impaired to glucose due to impaired glucose metabolism in these cells. We propose that endogenous generation of reactive oxygen species (ROS) and lactate overproduction play important roles in impaired glucose-induced insulin secretion in β-cells. 【Analysis of clinical data to elucidate pathophysiology of diabetes】We investigate the association between the histological severity of non-alcoholic fatty liver disease (NAFLD) and glucose tolerance. We also explore the possibility of the plasma mannose level as an indicator of glycogenolysis in human using clinical data of oral glucose tolerance tests in subjects with various degrees of glucose intolerance. Endocrinology 【Complication of Cushing syndrome】Persistent glucocorticoid excess (Cushing syndrome) causes several complications such as obesity, diabetes mellitus and osteoporosis. To clarify molecular mechanism in these complications, we investigate the phenotype of Cushing model mice (CRH transgenic mouse and corticosterone administered mice) in detail. We also examine circulating hormone levels (ACTH, cortisol, AgRP, etc) before and after surgery in patients with Cushing syndrome. 【Central pathophysiology of hyperphagia and obesity】Obesity is associated with adverse health outcomes (hypertension, diabetes mellitus, dyslipidemia, fatty liver, sleep apnea syndrome, etc) and is a growing problem worldwide. We investigate the pathophysiology of hyperphagia and obesity in the hypothalamus using diet-induced obese mice, gene-targeting mice (ob/ob mouse and AgRP knockout mouse) and hypothalamic cell line. Staff Department Name Professor Yoshio Terada Professor Shimpei Fujimoto Associate Professor Taro Horino Assistant Professor Takafumi Taguchi Assistant Professor Tatsuki Matsumoto Assistant Lecturer Yoshinori Taniguchi Assistant Lecturer Kazu Ode Assistant Lecturer Shogo Funakoshi Assistant Lecturer Seiki Hirano Assistant Lecturer Eri Amano Assistant Lecturer Inotani Satoshi Specially Appointed Assistant Lecturer Yuki Osakabe Kochi Medical SchoolDepartment of Endocrinology, Metabolism & Nephrology http://www.kochi-u.ac.jp/kms/fm_intr2/ TEL:+81-88-880-2343 Kochi Medical School／ Graduate School Medical Science Program, Nursing Science Program, Medicine Program Kohasu,Oko-cho,Nankoku-shi,Kochi 783-8505, JAPAN Contact About KMS Message from the Dean Campus map Outline Campus life Access Education Medical department Nursing Course Graduate School Kochi Medical School at rights reserved.