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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Molecular and Chemical Life Science :Chemical Biology Research HOME Research Researcher JAPANESE Professor OHASHI Kazumasa Campus Aobayama campus Laboratory Molecular and Cellular Biology Tel +81-22-795-6590 E-mail kazumasa.ohashi.b2＠tohoku.ac.jp Website https://konagata.wixsite.com/ohashi-lab I was the first to clone LIM-kinase (LIMK), and found that this protein phosphorylates and inhibits cofilin, an actin-severing and -depolymerizing factor. I have studied the role of the phospho-regulation of cofilin in actin cytoskeleton remodeling. Currently, I am interested in the molecular mechanisms of actin cytoskeleton remodeling by mechanical stresses and the role of actin cytoskeleton remodeling in the morphogenesis of epithelial cells. Career 1996 Ph.D., Department of Biology, Faculty of Science, Kyushu University. JSPS Research Fellowship for Young Scientists (PD), Kyushu University. 1997 JSPS Research Fellowship for Young Scientists (PD), Kyushu University. 1999 Assistant Professor, Faculty of Science, Tohoku University. 2001 Associate Professor, Graduate School of Life Sciences, Tohoku University. 2017 Professor, Graduate School of Life Sciences, Tohoku University. Selected Publications Yang, N., et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature, 393, 809-812 (1998). Abiko H., et al. Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells. J. Cell Sci. 128: 1683-1695 (2015) Fujiwara, S., et al. Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol. Biol. Cell, 27: 954-966 (2016). 他。 Activities in Academic Societies Japanese Biochemical Society, Molecular Biology Society of Japan, Japanese Cancer Association, Japan Neuroscience Society, Japan Society for Cell Biology, American Society for Cell Biology Teaching Biochemistry, Cell biology Recent Activities We are researching the molecular mechanisms underlying actin cytoskeleton remodeling and its roles in cell motility, migration, cell adhesion, and morphogenesis of epithelial cells. In particular, we focus on the molecular mechanisms of actin cytoskeleton remodeling by mechanical stresses in epithelial cells. We visualize the movements of dynamic changes in the actin cytoskeleton in living cells using fluorescent proteins, and analyze the functions of mechanotransduction molecules. Our aim is to understand unknown mechanisms of mechanotransduction and cell morphogenesis by analyzing the dynamic changes in cytoskeletal and signaling molecules in living cells. Message to Students Dynamic and ordered changes in the actin cytoskeleton are observed when cells move and change shape. Imaging the actin cytoskeleton in living cells using a fluorescence microscope is beautiful and mystifying (please see the video on our website). We are truly interested in elucidating the molecular mechanisms that control the dynamic structure inside a cell. Would you join us in this interesting research? 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