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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Medical Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease JAPANESEINQUIRY update：2021/12/17     NEXT PREV Features and Uniqueness Eleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity. Practical Application Development of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible. Keywords Recombinant inbred mouse MRL/lpr mouse C3H/lpr mouse Collagen disease Autoimmune disease Arthritis Glomerulonephritis Vasculitis Sialadenitis Gene analysis Researchers Graduate School of Biomedical Engineering Tetsuya KODAMA, ProfessorPhD (Engineering), PhD (Medicine) Laboratory Website researchmap Laboratory Website researchmap Related Information 1. Nose M, Komori H, Miyazaki T, Mori S. Genomics of vasculitis: lessons from mouse models.　Ann Vasc Dis. 2013;6(1):16-21. doi: 10.3400/avd.oa.12.00096. 2. Yuki Tanaka, Hiroaki Komori, Shiro Mori, Yoshiko Soga, Takahito Tsubaki, Miho Terada, Tatsuhiko Miyazaki, Takahiro Fujino, Satoshi Nakamura, Hiroyuki Kanno, Tatsuya Sawasaki, Yaeta Endo, Masato Nose. Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System. Tohoku J Exp Med. 2010 Mar;220(3):199-206. doi: 10.1620/tjem.220.199. Browsing History Same Researcher Development of an intranodal administration method [ 小玉 哲也 教授 ] Lymph node metastasis prediction and treatment evaluation system [ 小玉 哲也 教授 ] Development of McH-lpr/lpr-RA1 mouse, a study model that spontaneously develops severe autoimmune arthritis, vasculitis, and sialadenitis [ 小玉 哲也 教授 ] User Who Reviewed This Content Also Reviewed Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy [ SHIMOKAWA Hiroaki Professor ] Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries [ Hiroshi Kanai Professor ] “HYDRIDE" Researches for Energy Applications [ Shin-Ichi Orimo Professor ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close