ブラジル女子バレーメンバー

× {{flash.message}} Toggle navigation Toggle navigation 日本語 | English 新規登録ログイン 細川 まゆ子 ホソカワ マユコ  (Mayuko Hosokawa) 更新日: 01/31 ホーム研究キーワード研究分野学歴論文MISC書籍等出版物講演・口頭発表等担当経験のある科目(授業)所属学協会Works(作品等)共同研究・競争的資金等の研究課題 MISC 2016年1月1日 The effects of fluoride on the bones and teeth from ICR-derived glomerulonephritis (ICGN) mice and ICR mice after subacute exposure Fluoride Mayuko Hosokawa, Chiemi Sugaya, Masashi Tsunoda, Yukio Kodama, Yoshiko Sugita-Konishi, Hisayoshi Ohta, Kazuhito Yokoyama 巻 49 号 開始ページ 417 終了ページ 428 © 2016 The International Society for Fluoride Research Inc. Dental fluorosis and osteofluorosis from using drinking water contaminated with the fluoride ion (F) have been reported from many countries including the People’s Republic of China and India. Because fluoride is excreted by the kidney and the toxic effects of F are more severe when renal failure is present, Imprinting control region (ICR)-derived glomerulonephritis (ICGN) mice, which have been used as a model of renal failure, could be a useful model for osteofluorosis. In the present study, ICGN mice and ICR mice were administered F at 0, 25, 50, 100, and 150 ppm in their drinking water for 4 weeks. The femurs of the mice were photographed and analyzed by microdensitometry. The teeth were stained with hematoxylin and eosin. While no significant differences in any bone indexes were found in the ICGN groups, the mean values for bone mineral content and bone mineral density of the left femur from the male ICR 150 ppm group were significantly higher than those of the control group mice (p<0.001). Partial heterogeneous calcification of the tooth dentine was observed in the ICGN mice exposed to 150 ppm. ICGN mice may be used as a model for dental fluorosis. However, ICR mice, particularly males, with an exposure period of 2–4 mo, may be a better animal model for osteofluorosis. リンク情報 URLhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011534569&origin=inward ID情報 ISSN : 0015-4725SCOPUS ID : 85011534569 エクスポート BibTeX RIS MISCリストへ メニュー マイポータル 研究ブログ資料公開 共著者の一覧 まだ共著者が1人も登録されていません。 {{coauthor.Related.name_str}} {{coauthor.Related.last_modified}} 更新 limit"> もっとみる 2017 researchmap 利用規約